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Ryoji Nagai Selected Research

Diabetes Complications

11/2019Glucoselysine is derived from fructose and accumulates in the eye lens of diabetic rats.
7/2017Contribution of methylglyoxal to delayed healing of bone injury in diabetes.
6/2017High serum level of methylglyoxal-derived AGE, Nδ-(5-hydro-5-methyl-4-imidazolone-2-yl)-ornithine, independently relates to renal dysfunction.
4/2016Two new prenylflavonoids from Epimedii Herba and their inhibitory effects on advanced glycation end-products.
2/2014Inhibition of AGEs formation by natural products.
4/2012Lipid glycation and protein glycation in diabetes and atherosclerosis.
3/2012Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications.
4/2011An autoantibody against N(ε)-(carboxyethyl)lysine (CEL): possible involvement in the removal of CEL-modified proteins by macrophages.
4/2011Natural compounds containing a catechol group enhance the formation of Nε-(carboxymethyl)lysine of the Maillard reaction.
12/2010Glycolaldehyde induces oxidative stress in the heart: a clue to diabetic cardiomyopathy?
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Ryoji Nagai Research Topics

Disease

22Diabetes Complications
11/2019 - 01/2002
15Atherosclerosis
02/2014 - 06/2002
5Inflammation (Inflammations)
01/2022 - 05/2006
5Insulin Resistance
09/2021 - 12/2004
5Hyperglycemia
11/2019 - 08/2006
4Cataract (Cataracts)
01/2020 - 02/2010
4Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2017 - 02/2010
4Body Weight (Weight, Body)
06/2016 - 08/2006
4Diabetes Mellitus
09/2012 - 10/2003
4Diabetic Nephropathies (Diabetic Nephropathy)
11/2011 - 06/2005
4Diabetic Angiopathies (Diabetic Angiopathy)
06/2011 - 05/2006
3Chronic Kidney Failure (Chronic Renal Failure)
06/2013 - 08/2003
3Proteinuria
02/2010 - 10/2005
3Metabolic Syndrome (Dysmetabolic Syndrome X)
06/2005 - 12/2004
2Renal Insufficiency (Renal Failure)
06/2013 - 02/2010
2Hyperlipidemias (Hyperlipidemia)
03/2012 - 11/2007
2Obesity
03/2011 - 11/2007
2Hypoxia (Hypoxemia)
04/2009 - 02/2004
2Fibrosis (Cirrhosis)
12/2008 - 02/2008
2Renal Cell Carcinoma (Grawitz Tumor)
02/2008 - 08/2005
2Choroidal Neovascularization
01/2007 - 10/2004
2Atherosclerotic Plaque (Atheroma)
05/2006 - 12/2002
2Uremia
05/2006 - 10/2003
2Alzheimer Disease (Alzheimer's Disease)
02/2004 - 10/2003
1Arteriosclerosis
10/2020
1Eye Diseases (Eye Disease)
01/2020
1Hypopigmentation (Hypomelanosis)
01/2017
1Atrophy
01/2017
1Infections
07/2015
1Dyslipidemias (Dyslipidemia)
11/2014
1Septic Shock (Toxic Shock Syndrome)
10/2012
1Sepsis (Septicemia)
10/2012
1Osteoarthritis
10/2011
1Liver Diseases (Liver Disease)
03/2011
1Liver Failure
03/2011

Drug/Important Bio-Agent (IBA)

34Advanced Glycation End ProductsIBA
09/2021 - 01/2002
15Proteins (Proteins, Gene)FDA Link
11/2014 - 01/2002
9Streptozocin (Streptozotocin)FDA Link
01/2017 - 04/2008
6Glucose (Dextrose)FDA LinkGeneric
07/2017 - 01/2002
5PyridoxamineIBA
04/2016 - 04/2008
5N(6)-carboxymethyllysine (carboxymethyllysine)IBA
03/2011 - 04/2004
4pentosidineIBA
06/2013 - 08/2003
4Apolipoproteins E (ApoE)IBA
03/2012 - 11/2007
3Acyl Coenzyme A (Acyl CoA)IBA
03/2012 - 02/2008
3isoesculeogenin AIBA
03/2012 - 11/2007
3esculeoside AIBA
03/2012 - 11/2007
3CholesterolIBA
03/2012 - 02/2008
3CollagenIBA
02/2010 - 01/2002
3Advanced Oxidation Protein Products (AOPP)IBA
12/2008 - 05/2006
3Biological ProductsIBA
12/2007 - 05/2006
3LeptinIBA
06/2005 - 12/2004
2Crystallins (Crystallin)IBA
01/2019 - 02/2010
2Pyruvaldehyde (Methylglyoxal)IBA
07/2017 - 06/2017
2CreatinineIBA
06/2016 - 02/2008
2Glycated Serum AlbuminIBA
06/2016 - 03/2016
2benphothiamine (benfotiamine)IBA
02/2014 - 04/2012
2Biomarkers (Surrogate Marker)IBA
04/2012 - 11/2007
2TransferasesIBA
03/2012 - 04/2011
2NADPH Oxidases (NAD(P)H oxidase)IBA
06/2011 - 06/2010
2AntioxidantsIBA
03/2011 - 04/2008
2Glycoproteins (Glycoprotein)IBA
10/2007 - 08/2006
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
08/2007 - 08/2006
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2007 - 10/2004
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2007 - 10/2004
2NF-kappa B (NF-kB)IBA
08/2006 - 11/2002
2oxidized low density lipoproteinIBA
05/2006 - 12/2004
2Valine (L-Valine)FDA Link
10/2005 - 11/2002
2pyridineIBA
08/2005 - 12/2002
2LigandsIBA
06/2005 - 06/2005
1Histones (Histone)IBA
01/2022
1Carrier Proteins (Binding Protein)IBA
01/2022
1PlasminogenIBA
01/2022
1LuteinIBA
01/2020
1Arginine (L-Arginine)FDA Link
06/2017
1PhytochemicalsIBA
01/2017
1LipofuscinIBA
01/2017
1CarbohydratesIBA
06/2016
1KetonesIBA
03/2016
1Secretory Immunoglobulin A (SIgA)IBA
07/2015
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
11/2014
1pimagedine (aminoguanidine)IBA
02/2014
1Glycated ProteinsIBA
10/2012
1Lipid Bilayers (Lipid Bilayer)IBA
09/2012
1RyanodineIBA
09/2012
1Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA
09/2012
1LipidsIBA
04/2012
1Cholesterol Esters (Cholesteryl Esters)IBA
03/2012
1TomatineIBA
03/2012
1tomatidineIBA
03/2012
1alagebriumIBA
11/2011
1Matrix Metalloproteinase 14 (MT1-MMP)IBA
06/2011
1TriterpenesIBA
05/2011
1SugarsIBA
03/2011
1Adenosine Triphosphatases (ATPase)IBA
03/2011
1AldehydesIBA
12/2010
1glycolaldehydeIBA
12/2010

Therapy/Procedure

4Oral Administration
06/2016 - 08/2006
1Therapeutics
11/2014
1Glycemic Control
04/2012
1Chelation Therapy (Therapy, Chelation)
03/2012